Épisode 93 – Antidépresseurs et effets indésirables sexuels: une relation intime?

Un nouvel épisode du pharmascope est maintenant disponible! Dans de ce 93ème épisode, Nicolas, Sébastien et Isabelle reçoivent un invité pour discuter de tout ce qu’il y a à savoir sur les effets indésirables sexuels liés aux antidépresseurs. 

Les objectifs pour cet épisode sont les suivants:

  • Décrire les effets indésirables sexuels potentiels associés aux antidépresseurs
  • Expliquer les bénéfices et les inconvénients des diverses stratégies pouvant améliorer les plaintes sexuelles liées à la prise d’un antidépresseur

Ressources pertinentes en lien avec l’épisode

Serretti A, Chiesa A.  Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis.  J Clin Psychopharmacol. 2009 Jun;29(3):259-66.

Reichenpfeider U, Gartlehner G, Morgan LC, et coll. Sexual dysfunction associated with second-generation antidepressants in patients with major depressive disorder: results from a systematic review with network meta-analysis. Drug Saf. 2014 Jan;37(1):19-31.

Watanabe R, Omori IM, Nakagawa A, et coll. Mirtazapine versus other antidepressive agents for depression. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD006528.

Thase ME, Haight BR, Richard N et coll. Remission rates following antidepressant therapy with bupropion or selective serotonin reuptake inhibitors: a meta-analysis of original data from 7 randomized controlled trials. J Clin Psychiatry. 2005; 66(8): 974-81.

Delgado PL, Brannan SK, Mallinckrodt CH et coll. Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. J Clin Psychiatry. 2005; 66(6): 686-92.

Clayton A, Kornstein S, Prakash A et coll. Changes in sexual functioning associated with duloxetine, escitalopram, and placebo in the treatment of patients with major depressive disorder. J Sex Med. 2007; 4(4 Pt 1): 917-29.

Montejo-González AL, Llorca G, Izquierdo JA et coll. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther. 1997; 23(3): 176-94.

Jacobsen PL, Mahableshwarkar AR, Chen Y et coll. Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction. J Sex Med. 2015; 12(10): 2036-48.

Taylor MJ, Rudkin L, Bullemor-Day P et coll. Strategies for managing sexual dysfunction induced by antidepressant medication.Cochrane Database Syst Rev. 2013; (5): CD003382.

Clayton AH, Warnock JK, Kornstein SG et coll. A placebo-controlled trial of bupropion SR as an antidote for selective serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry. 2004 Jan;65(1):62-7.

Aizenberg D, Zemishlany Z, Weizman A. Clin Neuropharmacol. Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors. 1995; 18(4): 320-4.

Fava M, Dording CM, Baker RA, et coll. Effects of Adjunctive Aripiprazole on Sexual Functioning in Patients With Major Depressive Disorder and an Inadequate Response to Standard Antidepressant Monotherapy: A Post Hoc Analysis of 3 Randomized, Double-Blind, Placebo-Controlled Studies. Prim Care Companion CNS Disord. 2011; 13(1): PCC.10m00994.

Ravindran AV, Kennedy SH, O’Donovan MC, et coll. Osmotic-release oral system methylphenidate augmentation of antidepressant monotherapy in major depressive disorder: results of a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry. 2008 Jan;69(1):87-94.

Fooladi E, Bell RJ, Jane F, et coll. Testosterone improves antidepressant-emergent loss of libido in women: findings from a randomized, double-blind, placebo-controlled trial. J Sex Med. 2014 Mar;11(3):831-9.

Lorenz TA, Meston CM. Exercise improves sexual function in women taking antidepressants: results from a randomized crossover trial. Depress Anxiety. 2014 Mar;31(3):188-95.

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